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Resting state fMRI and clinical data from adolescents with remitted depression: A pilot study of rumination-focused cognitive behavior therapy
Principal Investigator(s): View help for Principal Investigator(s) Rachel Jacobs, University of Illinois at Chicago. Institute for Juvenile Research
Version: View help for Version V2
| Name | File Type | Size | Last Modified |
|---|---|---|---|
| Jacobs_RumCBT_Connect_PLOSONE_2016 | 11/03/2016 01:18:PM |
Project Citation:
Jacobs, Rachel. Resting state fMRI and clinical data from adolescents with remitted depression: A pilot study of rumination-focused cognitive behavior therapy. Ann Arbor, MI: Inter-university Consortium for Political and Social Research [distributor], 2016-11-03. https://doi.org/10.3886/E100281V2
Project Description
Summary:
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This pilot randomized control
trial was designed to examine whether Rumination-Focused Cognitive Behavior
Therapy (RFCBT) reduces rumination and residual depressive symptoms among
adolescents with a history of Major Depressive Disorder (MDD) who are at risk
for relapse. We also examined whether these changes in symptoms were associated
with changes in functional connectivity of the posterior cingulate cortex (PCC),
a key node in the default mode network (DMN). Thirty-three adolescents (ages
12-18) were randomized to eight weeks of RFCBT or an assessment only (AO)
control. Twenty two adolescents successfully completed fMRI scans pre- and
post-intervention. Adolescents were recruited from the clinic and community and
met criteria for at least one previous episode of MDD and were currently in
full or partial remission. An Independent Evaluator interviewed parent and
child before and after the eight-week intervention. The left PCC (-5, -50, 36)
seed was used to probe resting state functional connectivity of the DMN.
Adolescents who received RFCBT demonstrated reduced rumination (F = -2.76, df =
112, p < .01, 95% CI [-4.72,-0.80])
and self-report depression across eight weeks (F = -2.58, df = 113, p < .01, 95% CI [-4.21, -0.94]). Youth
who received RFCBT also demonstrated significant decreases in connectivity between
the left PCC and the right inferior frontal gyrus (IFG) and bilateral inferior
temporal gyri (ITG). Degree of change in connectivity was correlated with
changes in self-report depression and rumination. These data suggest that
rumination can be reduced over eight weeks and that this reduction is associated
with parallel decreases in residual depressive symptoms and decreased
functional connectivity of the left PCC with cognitive control nodes. These
changes may enhance the ability of vulnerable youth to stay well during the
transition to adulthood.
*From abstract of published article in PLOS ONE
*From abstract of published article in PLOS ONE
Funding Sources:
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Center for Clinical Translational Science at University of Illinois at Chicago (1UL1RR029879);
Klingenstein Third Generation Fund;
Mind and Life Institute
Scope of Project
Subject Terms:
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fmri;
adolescence;
depression (psychology)
Data Type(s):
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clinical data;
other
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